The flora of the Sierra Murrieta was inventoried on a Madrean Archipelago Biotic Assessment Expedition from July 31 to August 2, 2014, and a Madrean Discovery Expedition (MDE) on September 13-17, 2022. The vegetation is foothills thornscrub at lower elevations and oak woodland above. A unique feature is an open limestone habitat on the top of the Sierra Murrieta. The flora has strong floristic affinities with tropical southern Sonora and the temperate Sierra Madre Occidental and Sky Island mountain ranges in the Madrean Archipelago.